The nicest city the most miserable

Mathematical academical life has given me many opportunities to visit cities around Europe, to enjoy more than just a small amount of time there and not to run the usual stressing touristic race around all "must-see" sights.
On the contrary, I was able/had to take the viewpoint of an ordinary inhabitant and take at least a sip of a daily life there. This formed my view on cities in general as well as my opinion on many European metropoleis.

• I have great memories of Amsterdam, (among other reasons) for its public "street night skating" with a friendly atmosphere run weekly (dry streets permitting) all year round.
• I admire Paris for its incredibly dense net of rental spots of city-bikes, that can be used for a very friendly price.
• A great example of competition in public transportation can be found in Catalan metropolis: three different metro/railway systems (more or less successfully) work hard for the comfort of people of Barcelona.
• My biggest impression from my short visit of Zurich were the modern terraces built onto old roofs of almost all buildings around our hotel and people enjoying silent evenings with beautiful views from there.

Of course, for your life (in a city), the thing that matters most is other people around. But should the city be an obstacle for the life of "your community" or a pleasant environment? Should the city serve to the tourists, preservationists, and historicians or to its inhabitants?

So what about "my city"? No matter how hard I think, I can not figure out any reason why should I include it into my nice list. Can you help me somebody, please?
I would love to change my view of the city of Prague as the most beautiful, the most miserable.